When they utilize their abilities, the panacea formula in their blood loses its purity and begins to stagnate, causing what should be a source of power to instead become a deadly poison. In addition to regularly undergoing dialysis, whenever they use a large amount of power (such as in a battle with the Symphogear users), they must replace nearly all of their blood. Despite being feared as monsters, the fact that this makes Noble Red unreliable as weapons is undeniable.
Finally, the panacea formula requires the rare blood type "RH xxoyle_formula", present in only 1 in 1.4 million people. The difficulty in acquiring it is yet another reason why Noble Red's members are considered to be failures.
It was first used in XV Episode 3 of XV season by Millaarc Cranstoun and Elsa Bête at the end of the episode. Vanessa Diodati is not seen to be using it due to the fact that she didn't fully utilize her abilities yet.XV Episode 10 of XV season, Noble Red no longer needed the formula as they have changed their bodies into perfect monster forms by Shem-Ha who immediately killed them upon awakening, but she nonetheless revived them, then enlisted them into fulfilling her plans, informing them of her plan to return the world to the way it was 5000 years ago.
- The Rh blood group system is one of forty-five known human blood group systems and is the second most important blood group system, after the ABO blood group system.
- The term "Rh" was originally an abbreviation of "Rhesus factor".